Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex

The main purpose of this work was to compare the effects four preparation methods on TFLX/HP-β-CD inclusion complex. different complex were investigated by SEM, DSC, PXRD, FT-IR and 1H NMR. All characterization information indicated that could cause interaction between TFLX HP-β-CD, but prepared solvent evaporation has more reaction sites. Phase solubility experiments demonstrated spontaneous. In vitro dissolution showed in water was: method (64.39%) > grinding (42.37%) ultrasonic (40.00%) freezing (36.08%), all higher than pure physical mixture. These results suggest is most suitable for preparing complexes.